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De novo cutaneous connective tissue disease temporally associated with immune checkpoint inhibitor therapy: A retrospective analysis To the Editor: With the success of immune checkpoint inhibitors (ICI) in cancer therapy, there is urgency to better characterize dermatologic immune-related adverse events (irAEs). De novo cutaneous connective tissue disease (CTD) has been associated with immunotherapy including reports of

2 cases of scleroderma, 7 cases of dermatomyositis, 6 cases of subacute cutaneous lupus erythematosus (SCLE), and 11 cases of eosinophilic fasciitis (EF). 1, 2 In this study, we evaluated the frequency of immunotherapy-associated de novo cutaneous CTD among our institutions and reported clinical features and management. In this retrospective cohort study, we queried electronic pharmacy and medical records to find the total number of adult patients treated with pembrolizumab …