作者
Andrew C Hayward, Ellen B Fragaszy, Alison Bermingham, Lili Wang, Andrew Copas, W John Edmunds, Neil Ferguson, Nilu Goonetilleke, Gabrielle Harvey, Jana Kovar, Megan SC Lim, Andrew McMichael, Elizabeth RC Millett, Jonathan S Nguyen-Van-Tam, Irwin Nazareth, Richard Pebody, Faiza Tabassum, John M Watson, Fatima B Wurie, Anne M Johnson, Maria Zambon
发表日期
2014/6/1
期刊
The Lancet Respiratory Medicine
卷号
2
期号
6
页码范围
445-454
出版商
Elsevier
简介
Background
Assessment of the effect of influenza on populations, including risk of infection, illness if infected, illness severity, and consultation rates, is essential to inform future control and prevention. We aimed to compare the community burden and severity of seasonal and pandemic influenza across different age groups and study years and gain insight into the extent to which traditional surveillance underestimates this burden.
Methods
Using preseason and postseason serology, weekly illness reporting, and RT-PCR identification of influenza from nasal swabs, we tracked the course of seasonal and pandemic influenza over five successive cohorts (England 2006–11; 5448 person-seasons' follow-up). We compared burden and severity of seasonal and pandemic strains. We weighted analyses to the age and regional structure of England to give nationally representative estimates. We compared symptom profiles …
学术搜索中的文章
AC Hayward, EB Fragaszy, A Bermingham, L Wang… - The Lancet Respiratory Medicine, 2014