作者
Heba Zahid, Evan R Simpson, Kristy A Brown
发表日期
2016/12/1
来源
Current opinion in pharmacology
卷号
31
页码范围
90-96
出版商
Elsevier
简介
Highlights
- Obesity is associated with chronic low-grade inflammation in the breast tissue.
- WATi is characterized by the presence of crown-like structures (CLS-B).
- CLS-B increases inflammatory mediators TNFα, IL-6, IL-1β and COX-2-derived PGE2.
- PGE2 stimulates aromatase via its effect on LKB1/AMPK, CREB/CRTC2, p53 and HIF1α.
- Reduction of estrogen and inflammation reduces the risk of developing breast cancer.
Obesity is associated with an increased risk of estrogen-dependent breast cancer after menopause. Adipose tissue undergoes important changes in obesity due to excess storage of lipids, leading to adipocyte cell death and the recruitment of macrophages. The resultant state of chronic low-grade inflammation is associated with the activation of NFkB signaling and elevated levels of aromatase, the rate-limiting enzyme in estrogen biosynthesis. This occurs not only in the visceral and subcutaneous fat …
学术搜索中的文章
H Zahid, ER Simpson, KA Brown - Current opinion in pharmacology, 2016