作者
Jennifer L Lofgren, Mark T Whary, Zhongming Ge, Sureshkumar Muthupalani, Nancy S Taylor, Melissa Mobley, Amanda Potter, Andrea Varro, Daniel Eibach, Sebastian Suerbaum, Timothy C Wang, James G Fox
发表日期
2011/1/1
期刊
Gastroenterology
卷号
140
期号
1
页码范围
210-220. e4
出版商
WB Saunders
简介
BACKGROUND & AIMS
Transgenic FVB/N insulin-gastrin (INS-GAS) mice have high circulating gastrin levels, and develop spontaneous atrophic gastritis and gastrointestinal intraepithelial neoplasia (GIN) with 80% prevalence 6 months after Helicobacter pylori infection. GIN is associated with gastric atrophy and achlorhydria, predisposing mice to nonhelicobacter microbiota overgrowth. We determined if germfree INS-GAS mice spontaneously develop GIN and if H pylori accelerates GIN in gnotobiotic INS-GAS mice.
METHODS
We compared gastric lesions, levels of messenger RNA, serum inflammatory mediators, antibodies, and gastrin among germfree and H pylori–monoinfected INS-GAS mice. Microbiota composition of specific pathogen-free (SPF) INS-GAS mice was quantified by pyrosequencing.
RESULTS
Germfree INS-GAS mice had mild hypergastrinemia but did not develop significant gastric lesions …
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JL Lofgren, MT Whary, Z Ge, S Muthupalani, NS Taylor… - Gastroenterology, 2011