作者
Jan Menne, Martin Nitschke, Robert Stingele, Mariam Abu-Tair, Jan Beneke, Jörn Bramstedt, Jan P Bremer, Reinhard Brunkhorst, Veit Busch, Reinhard Dengler, Günther Deuschl, Klaus Fellermann, Helmut Fickenscher, Christoph Gerigk, Alexander Goettsche, Jobst Greeve, Carsten Hafer, Friedrich Hagenmüller, Hermann Haller, Stefan Herget-Rosenthal, Bernd Hertenstein, Christina Hofmann, Melanie Lang, Jan T Kielstein, Ulrich C Klostermeier, Johannes Knobloch, Markus Kuehbacher, Ulrich Kunzendorf, Hendrik Lehnert, Michael P Manns, Tobias F Menne, Tobias N Meyer, Claus Michael, Thomas Münte, Christine Neumann-Grutzeck, Jens Nuernberger, Hermann Pavenstaedt, Leyla Ramazan, Lutz Renders, Jonas Repenthin, Wolfgang Ries, Axel Rohr, Lars Christian Rump, Ola Samuelsson, Friedhelm Sayk, Bernhard MW Schmidt, Sabine Schnatter, Harald Schöcklmann, Stefan Schreiber, Cay U von Seydewitz, Jürgen Steinhoff, Sylvia Stracke, Sebastian Suerbaum, Andreas van de Loo, Martin Vischedyk, Karin Weissenborn, Peter Wellhöner, Monika Wiesner, Sebastian Zeissig, Jürgen Büning, Mario Schiffer, Tanja Kuehbacher
发表日期
2012/7/19
期刊
Bmj
卷号
345
出版商
British Medical Journal Publishing Group
简介
Objective To evaluate the effect of different treatment strategies on enterohaemorrhagic Escherichia coli O104:H4 induced haemolytic uraemic syndrome.
Design Multicentre retrospective case-control study.
Setting 23 hospitals in northern Germany.
Participants 298 adults with enterohaemorrhagic E coli induced haemolytic uraemic syndrome.
Main outcome measures Dialysis, seizures, mechanical ventilation, abdominal surgery owing to perforation of the bowel or bowel necrosis, and death.
Results 160 of the 298 patients (54%) temporarily required dialysis, with only three needing treatment long term. 37 patients (12%) had seizures, 54 (18%) required mechanical ventilation, and 12 (4%) died. No clear benefit was found from use of plasmapheresis or plasmapheresis with glucocorticoids. 67 of the patients were treated with eculizumab, a monoclonal antibody directed against the complement cascade. No short term …
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J Menne, M Nitschke, R Stingele, M Abu-Tair, J Beneke… - Bmj, 2012