作者
Peter J Peters, Jacques J Neefjes, Viola Oorschot, Hidde L Ploegh, Hans J Geuze
发表日期
1991/2/21
期刊
Nature
卷号
349
期号
6311
页码范围
669-676
出版商
Nature Publishing Group UK
简介
Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively. In human B lymphoblastoid cells, class I molecules are present in compartments constituting the biosynthetic pathway, whereas class II molecules enter structures related to lysosomes during their biosynthesis.
引用总数
学术搜索中的文章
PJ Peters, JJ Neefjes, V Oorschot, HL Ploegh… - Nature, 1991