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The topic of this presentation is the investigation of the epileptic human brain as a nonlinear system that undergoes a phase transition (epileptic seizure). The estimated values of the largest Lyapunov exponent L over time indicated a more chaotic state postictally than ictally or preictally. The start of a seizure corresponds to a simultaneous drop in the values of L at the focal electrode sites.

The observed slow cyclic variations in the temporal Lyapunov profiles imply attempts of the system to undergo a phase transition minutes before the seizure’s onset. The analysis of the maximum rate of entropy production over space revealed an initial phase difference of minutes preictally at the sites overlying the seizure focus, which progressed to phase locking with a slow entrainment of the rest of the cortical sites shortly before the onset of a seizure. It is also conjectured that the abnormal spiking electrical activity of the brain plays a major role in the unfolding of the phenomenon.