作者
Gilbert Mühlmann, Gilbert Spizzo, Johanna Gostner, Matthias Zitt, Hans Maier, Patrizia Moser, Günther Gastl, HM Müller, R Margreiter, D Öfner, D Fong
发表日期
2009/2/1
期刊
Journal of clinical pathology
卷号
62
期号
2
页码范围
152-158
出版商
BMJ Publishing Group
简介
Background
In gastric cancer the recurrence rate is unacceptably high, even after R0 resection and (neo)adjuvant chemotherapy. Therefore, there is an urgent need for identification of predictive and/or prognostic biomarkers to select high-risk patients who might benefit from additional therapies. Expression of TROP2 has been shown to be associated with tumour aggressiveness and poor prognosis in patients with various epithelial cancers.
Aims
To investigate TROP2 expression in gastric cancer and its correlation with clinicopathological features and disease outcome.
Methods
Expression of TROP2 was investigated by immunohistochemistry of tumour specimens from 104 patients who underwent resection for gastric cancer. Parameters found to be of prognostic significance in univariate analysis were verified in a multivariate Cox regression model.
Results
TROP2 was found to be overexpressed in 58 (56%) tumour …
引用总数
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