作者
Karlheinz Ammann, Werner Kirchmayr, Alexander Klaus, Gilbert Mühlmann, Reinhold Kafka, Michael Oberwalder, Alexander De Vries, Dietmar Öfner, Helmut Weiss
发表日期
2003/3/1
期刊
Archives of surgery
卷号
138
期号
3
页码范围
257-261
出版商
American Medical Association
简介
Hypothesis
Preoperative chemoradiation for patients with stage II and III midrectal and low rectal cancer may improve survival and decrease local recurrence rate. We evaluated the long-term impact of neoadjuvant chemoradiation on anal sphincter function.
Design
Prospective analysis.
Setting
Tertiary referral center.
Patients
From March 1, 1996, to January 31, 2002, 50 patients with midrectal and low rectal cancer who underwent total mesorectal excision were prospectively enrolled.
Interventions
Patients received either surgical therapy alone (group 1, n = 22) or preoperative, combined chemoradiation (group 2, n = 28). Group 2 was divided into patients with midrectal (group 2A, n = 14) and low rectal (group 2B, n = 14) cancer. Anorectal manometry was performed preoperatively and a median of 384 days postoperatively.
Main Outcome Measures
Anal resting pressure, squeeze pressure, anal sphincter vector volumes …
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