作者
Ilana Fox-Fisher, Sheina Piyanzin, Mayan Briller, Esther Oiknine-Djian, Or Alfi, Roni Ben-Ami, Ayelet Peretz, Daniel Neiman, Bracha-Lea Ochana, Ori Fridlich, Zeina Drawshy, Agnes Klochendler, Judith Magenheim, Danielle Share, Ran Avrahami, Yaarit Ribak, Aviv Talmon, Limor Rubin, Neta Milman, Meital Segev, Erik Feldman, Yuval Tal, Shai S Shen-Orr, Benjamin Glaser, Ruth Shemer, Dana Wolf, Yuval Dor
发表日期
2022/7/8
期刊
Med
卷号
3
期号
7
页码范围
468-480. e5
出版商
Elsevier
简介
Background
Much remains unknown regarding the response of the immune system to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination.
Methods
We employed circulating cell-free DNA (cfDNA) to assess the turnover of specific immune cell types following administration of the Pfizer/BioNTech vaccine.
Findings
The levels of B cell cfDNA after the primary dose correlated with development of neutralizing antibodies and memory B cells after the booster, revealing a link between early B cell turnover—potentially reflecting affinity maturation—and later development of effective humoral response. We also observed co-elevation of B cell, T cell, and monocyte cfDNA after the booster, underscoring the involvement of innate immune cell turnover in the development of humoral and cellular adaptive immunity. Actual cell counts remained largely stable following vaccination, other than a previously …
学术搜索中的文章
I Fox-Fisher, S Piyanzin, M Briller, E Oiknine-Djian… - Med, 2022