作者
Marc Barritault, Thiébaud Picart, Delphine Poncet, Tanguy Fenouil, Anne d’Hombres, Mathieu Gabut, Jacques Guyotat, Emmanuel Jouanneau, Roxana Ameli, Bastien Joubert, Nathalie Streichenberger, Alexandre Vasiljevic, Jérôme Honnorat, David Meyronet, François Ducray
发表日期
2020/10/1
期刊
Neurosurgery
卷号
87
期号
4
页码范围
E513-E519
出版商
LWW
简介
OBJECTIVE
To explore the utility of molecular testing in this setting by determining whether IDH1 and TERT promoter (pTERT) mutations could be detected in nondiagnostic biopsies from glioma patients.
METHODS
Using SNaPshot polymerase chain reaction, we retrospectively assessed IDH1 and pTERT mutation status in nondiagnostic biopsies from 28 glioma patients.
RESULTS
The nondiagnostic biopsy (needle biopsy n= 25, open or endoscopic biopsy n= 3) consisted of slight glial cell hypercellularity, hemorrhage, and/or necrosis. After another biopsy (n= 23) or a subsequent surgical resection (n= 5) the diagnosis was an IDH1-wildtype (WT) pTERT-mutant glioma (glioblastoma n= 16, astrocytoma n= 4), an IDH1-mutant pTERT-mutant oligodendroglioma (n= 1), an IDH1-mutant pTERT-WT astrocytoma (n= 1), and an IDH1-WT pTERT-WT glioblastoma (n= 6). An IDH1 mutation was identified in the nondiagnostic …
引用总数
2020202120222023202411121