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Background

Migraine is a chronic disabling neurovascular condition that may in part be caused by endothelial and cerebrovascular disruption induced by hyperhomocysteinaemia. We have previously provided evidence indicating that reduction of homocysteine by vitamin supplementation can reduce the occurrence of migraine in women. The current study examined the genotypic effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene variants on the occurrence of migraine in response to vitamin supplementation.

Methods

This was a 6-month randomized, double-blinded placebo-controlled trial of daily vitamin B supplementation (B 6, B 9 and B 12) on reduction of homocysteine and of the occurrence of migraine in 206 female patients diagnosed with migraine with aura.

Results

Vitamin supplementation significantly reduced homocysteine levels (P< 0.001), severity …