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Background

Migraine is a prevalent and debilitating disease that may, in part, arise because of disruption in neurovascular endothelia caused by elevated homocysteine. This study examined the homocysteine-lowering effects of vitamin supplementation on migraine disability, frequency and severity and whether MTHFRC677T genotype influenced treatment response.

Methods

This was a randomized, double-blind placebo, controlled trial of 6 months of daily vitamin supplementation (ie 2 mg of folic acid, 25 mg vitamin B 6, and 400 μg of vitamin B 12) in 52 patients diagnosed with migraine with aura.