作者
Rod A Lea, A Dohy, K Jordan, S Quinlan, PJ Brimage, LR Griffiths
发表日期
2000/10
期刊
Neurogenetics
卷号
3
页码范围
35-40
出版商
Springer-Verlag
简介
Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the type and number of genes involved is not yet clear. However, the calcium channel gene, CACNA1A , on chromosome 19 contains mutations responsible for familial hemiplegic migraine, a rare and severe subtype of migraine. There is also evidence to suggest that serotonin- and dopamine-related genes may be involved in the pathogenesis of migraine. This study employed a linkage and association approach to investigate neurotransmitter-related migraine candidate genes. Polymorphisms within the dopamine beta-hydroxylase ( DBH ) gene, serotonin transporter gene ( SERT …
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