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Chromatographic separation of the CH₂Cl₂ extract from leaves of Peperomia serpens yielded two chromenes [5-hydroxy-8-(3′,7′-dimethylocta-2′,6′-dienyl)-2,2,7-trimethyl-2H-1-chromene (1) and 5-hydroxy-8-(3′-methyl-2′-butenyl)-2,2,7-trimethyl-2H-1-chromene-6-carboxylic acid (2)], besides the known chromene [methyl 5-hydroxy-2,2,7-trimethyl-2H-1-chromene-6-carboxylate (3)] and the flavonoid, dihydrooroxylin (4). Their structural elucidation were achieved by spectroscopic analyses. The antifungal activities of the CH₂Cl₂ extract and the isolated chromenes were measured bioautographically against Cladosporium cladosporioides and C. sphaerospermum, when it was found that the crude extract showed higher activity as compared to the pure compounds.