作者
Sonia Herraiz, Mónica Romeu, Anna Buigues, Susana Martínez, César Díaz-García, Inés Gómez-Seguí, José Martínez, Nuria Pellicer, Antonio Pellicer
发表日期
2018/8/1
期刊
Fertility and sterility
卷号
110
期号
3
页码范围
496-505. e1
出版商
Elsevier
简介
Objective
To evaluate effects of autologous stem cell ovarian transplant (ASCOT) on ovarian reserve and IVF outcomes of women who are poor responders with very poor prognosis.
Design
Prospective observational pilot study.
Setting
University hospital.
Patient(s)
Seventeen women who are poor responders.
Intervention(s)
Ovarian infusion of bone marrow-derived stem cells.
Main Outcome Measure(s)
Serum antimüllerian hormone levels and antral follicular count (AFC), punctured follicles, and oocytes retrieved after stimulation (controlled ovarian stimulation) were measred. Apheresis was analyzed for growth factor concentrations.
Result(s)
The ASCOT resulted in a significant improvement in AFC 2 weeks after treatment. With an increase in AFC of three or more follicles and/or two consecutive increases in antimüllerian hormone levels as success criteria, ovarian function improved in 81.3% of women. These positive …
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