作者
Perry G Ridge, Kaitlyn B Hoyt, Kevin Boehme, Shubhabrata Mukherjee, Paul K Crane, Jonathan L Haines, Richard Mayeux, Lindsay A Farrer, Margaret A Pericak-Vance, Gerard D Schellenberg, John SK Kauwe, Perrie M Adams, Marilyn S Albert, Roger L Albin, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Clinton T Baldwin, Robert C Barber, Michael M Barmada, Lisa L Barnes, Sandra Barral, Thomas G Beach, James T Becker, Gary W Beecham, Duane Beekly, David A Bennett, Eileen H Bigio, Thomas D Bird, Deborah Blacker, Bradley F Boeve, James D Bowen, Adam Boxer, James R Burke, Jeffrey M Burns, Joseph D Buxbaum, Nigel J Cairns, Laura B Cantwell, Chuanhai Cao, Chris S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Steven L Carroll, Helena C Chui, David G Clark, Jason Corneveaux, David H Cribbs, Elizabeth A Crocco, Carlos Cruchaga, Philip L De Jager, Charles DeCarli, F Yesim Demirci, Malcolm Dick, Dennis W Dickson, Rachelle S Doody, Ranjan Duara, Nilufer Ertekin-Taner, Denis A Evans, Kelley M Faber, Thomas J Fairchild, Kenneth B Fallon, David W Fardo, Martin R Farlow, Steven Ferris, Tatiana M Foroud, Matthew P Frosch, Douglas R Galasko, Marla Gearing, Daniel H Geschwind, Bernardino Ghetti, John R Gilbert, Alison M Goate, Neill R Graff-Radford, Robert C Green, John H Growdon, Hakon Hakonarson, Ronald L Hamilton, Kara L Hamilton-Nelson, John Hardy, Lindy E Harrell, Lawrence S Honig, Ryan M Huebinger, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Gail P Jarvik, Gregory A Jicha, Lee-Way Jin, Gyungah Jun, M Ilyas Kamboh, Anna Karydas, Mindy J Katz, Jeffrey A Kaye, Ronald Kim, Neil W Kowall, Joel H Kramer, Walter A Kukull, Brian W Kunkle, Frank M LaFerla, James J Lah, Eric B Larson, James B Leverenz, Allan I Levey, Ge Li, Andrew P Lieberman, Chiao-Feng Lin, Richard B Lipton, Oscar L Lopez, Kathryn L Lunetta, Constantine G Lyketsos, Wendy J Mack, Daniel C Marson, Eden R Martin, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Wayne C McCormick, Susan M McCurry, Andrew N McDavid, Ann C McKee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, Thomas J Montine, John C Morris, Jill R Murrell, Amanda J Myers, Adam C Naj, Sid O'Bryant, John M Olichney, Vernon S Pankratz, Joseph E Parisi, Amanda Partch, Henry L Paulson, William Perry, Elaine Peskind, Ronald C Petersen, Aimee Pierce, Wayne W Poon, Huntington Potter, Joseph F Quinn, Ashok Raj, Murray Raskind, Eric M Reiman, Barry Reisberg, Joan S Reisch, Christiane Reitz
发表日期
2016/5/1
期刊
Neurobiology of aging
卷号
41
页码范围
200. e13-200. e20
出版商
Elsevier
简介
Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. More than 20 common markers have been identified, which are associated with AD. Recently, several rare variants have been identified in Amyloid Precursor Protein (APP), Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) and Unc-5 Netrin Receptor C (UNC5C) that affect risk for AD. Despite the many successes, the genetic architecture of AD remains unsolved. We used Genome-wide Complex Trait Analysis to (1) estimate phenotypic variance explained by genetics; (2) calculate genetic variance explained by known AD single nucleotide polymorphisms (SNPs); and (3) identify the genomic locations of variation that explain the remaining unexplained genetic variance. In total, 53.24% of phenotypic variance is explained by genetics, but known AD SNPs only explain 30.62% of the genetic variance. Of the unexplained …
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PG Ridge, KB Hoyt, K Boehme, S Mukherjee, PK Crane… - Neurobiology of aging, 2016