作者
Andrea Pirzkall, Tracy R McKnight, Edward E Graves, Mark P Carol, Penny K Sneed, William W Wara, Sarah J Nelson, Lynn J Verhey, David A Larson
发表日期
2001/7/15
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
50
期号
4
页码范围
915-928
出版商
Elsevier
简介
Purpose
Functional/metabolic information provided by MR-spectroscopy (MRSI) suggests MRI may not be a reliable indicator of active and microscopic disease in malignant brain tumors. We assessed the impact MRSI might have on the target volumes used for radiation therapy treatment planning for high-grade gliomas.
Methods and Materials
Thirty-four patients (22 Grade III; 12 Grade IV astrocytomas) were evaluated; each had undergone MRI and MRSI studies before surgery. MRI data sets were contoured for T1 region of contrast enhancement (T1), region of necrosis, and T2 region of hyperintensity (T2). The three-dimensional MRSI peak parameters for choline (Cho) and N-acetylaspartate (NAA), acquired by a multivoxel technique, were categorized based on an abnormality index (AI), a quantitative assessment of tissue metabolite levels. The AI data were aligned to the MRI and displayed as three …
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A Pirzkall, TR McKnight, EE Graves, MP Carol… - International Journal of Radiation Oncology* Biology …, 2001