作者
Craig L Phillips, Ronald R Grunstein, M Ali Darendeliler, Anastasia S Mihailidou, Vasantha K Srinivasan, Brendon J Yee, Guy B Marks, Peter A Cistulli
发表日期
2013/4/15
期刊
American journal of respiratory and critical care medicine
卷号
187
期号
8
页码范围
879-887
出版商
American Thoracic Society
简介
Rationale: Continuous positive airway pressure (CPAP) and mandibular advancement device (MAD) therapy are commonly used to treat obstructive sleep apnea (OSA). Differences in efficacy and compliance of these treatments are likely to influence improvements in health outcomes.
Objectives: To compare health effects after 1 month of optimal CPAP and MAD therapy in OSA.
Methods: In this randomized crossover trial, we compared the effects of 1 month each of CPAP and MAD treatment on cardiovascular and neurobehavioral outcomes.
Measurements and Main Results: Cardiovascular (24-h blood pressure, arterial stiffness), neurobehavioral (subjective sleepiness, driving simulator performance), and quality of life (Functional Outcomes of Sleep Questionnaire, Short Form-36) were compared between treatments. Our primary outcome was 24-hour mean arterial pressure. A total of 126 patients with moderate …
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CL Phillips, RR Grunstein, MA Darendeliler… - American journal of respiratory and critical care …, 2013