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Results: Plasma resistin and resistin: adiponectin ratio were higher in asthma compared to controls [7.2 (4.8-9.6) vs. 4.8 (3.7-7.3) ng/mL, p ¼ 0.005 and 3.04±0.58 vs. 1.55±0.23 Â 10-3, p ¼ 0.019 respectively] and further increased in subjects with a severe asthma pattern. Resistin: adiponectin ratio was increased in obese asthma compared to non-obese asthma and non-obese controls. Resistin: adiponectin ratio was increased in obese females, non-obese males and obese males compared to nonobese females. Using multiple linear regression, both resistin and resistin: adiponectin negatively predicted lung function. Following weight loss, resistin and resistin: adiponectin ratio were unchanged. However, change in% body fat was associated with change in resistin: adiponectin ratio. Conclusions: Resistin: adiponectin ratio is increased in asthma and further increased in subjects who are obese, have more severe disease and are male. As resistin and resistin: adiponectin ratio negatively predict lung function, these adipokines may provide a therapeutic target for obese asthma.