查看文章

A recombinant live attenuated tetravalent dengue vaccine (TDV) is safe and immunogenic in adults and children in dengue-naïve populations. Data are needed in dengue endemic populations. In a phase I, randomized, controlled, blind-observer study in the Philippines, groups of participants aged 2–5, 6–11, 12–17, and 18–45 years received either three TDV vaccinations at months 0, 3.5, and 12 (TDV–TDV–TDV group) or licensed typhoid vaccination at month 0 and TDV at months 3.5 and 12 (TyVi–TDV–TDV group) and were followed for safety (including biological safety and vaccine virus viremia) and immunogenicity. No serious adverse vaccine related events and no significant trends in biological safety parameters were reported. Injection site pain, headache, malaise, myalgia, fever, and asthenia were reported most frequently, as mild to moderate in most cases and transient. Reactogenicity did not increase …