作者
Jonathan Witton, Lydia E Staniaszek, Ullrich Bartsch, Andrew D Randall, Matthew W Jones, Jonathan T Brown
发表日期
2016/8/15
期刊
The Journal of physiology
卷号
594
期号
16
页码范围
4615-4630
简介
Key points
- High frequency (100–250 Hz) neuronal oscillations in the hippocampus, known as sharp‐wave ripples (SWRs), synchronise the firing behaviour of groups of neurons and play a key role in memory consolidation.
- Learning and memory are severely compromised in dementias such as Alzheimer's disease; however, the effects of dementia‐related pathology on SWRs are unknown.
- The frequency and temporal structure of SWRs was disrupted in a transgenic mouse model of tauopathy (one of the major hallmarks of several dementias).
- Excitatory pyramidal neurons were more likely to fire action potentials in a phase‐locked manner during SWRs in the mouse model of tauopathy; conversely, inhibitory interneurons were less likely to fire phase‐locked spikes during SWRs.
- These findings indicate there is reduced inhibitory control of hippocampal network events and point to a novel mechanism which may …
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J Witton, LE Staniaszek, U Bartsch, AD Randall… - The Journal of physiology, 2016