作者
Risto Näätänen, Teija Kujala, Kairi Kreegipuu, Synnöve Carlson, Carles Escera, Torsten Baldeweg, Curtis Ponton
发表日期
2011/12/1
来源
Brain
卷号
134
期号
12
页码范围
3435-3453
出版商
Oxford University Press
简介
Cognitive impairment is a core element shared by a large number of different neurological and neuropsychiatric diseases. Irrespective of their different aetiologies and symptomatologies, most appear to converge at the functional deficiency of the auditory-frontal cortex network of auditory discrimination, which indexes cognitive impairment shared by these abnormalities. This auditory-frontal cortical deficiency, and hence cognitive decline, can now be objectively measured with the mismatch negativity and its magnetic equivalent. The auditory-frontal cortical network involved seems, therefore, to play a pivotal, unifying role in the different abnormalities. It is, however, more likely that the dysfunction that can be detected with the mismatch negativity and its magnetoencephalographic equivalent manifests a more widespread brain disorder, namely, a deficient N-methyl-d-aspartate receptor function, shared by these …
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R Näätänen, T Kujala, K Kreegipuu, S Carlson… - Brain, 2011