作者
Najib M El-Sayed, Peter J Myler, Gaëlle Blandin, Matthew Berriman, Jonathan Crabtree, Gautam Aggarwal, Elisabet Caler, Hubert Renauld, Elizabeth A Worthey, Christiane Hertz-Fowler, Elodie Ghedin, Christopher Peacock, Daniella C Bartholomeu, Brian J Haas, Anh-Nhi Tran, Jennifer R Wortman, U Cecilia M Alsmark, Samuel Angiuoli, Atashi Anupama, Jonathan Badger, Frederic Bringaud, Eithon Cadag, Jane M Carlton, Gustavo C Cerqueira, Todd Creasy, Arthur L Delcher, Appolinaire Djikeng, T Martin Embley, Christopher Hauser, Alasdair C Ivens, Sarah K Kummerfeld, Jose B Pereira-Leal, Daniel Nilsson, Jeremy Peterson, Steven L Salzberg, Joshua Shallom, Joana C Silva, Jaideep Sundaram, Scott Westenberger, Owen White, Sara E Melville, John E Donelson, Björn Andersson, Kenneth D Stuart, Neil Hall
发表日期
2005/7/15
期刊
Science
卷号
309
期号
5733
页码范围
404-409
出版商
American Association for the Advancement of Science
简介
A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and subtelomeric regions. Retroelements, structural RNAs, and gene family expansion are often associated with syntenic discontinuities that—along with gene divergence, acquisition and loss, and rearrangement within the syntenic regions—have shaped the genomes of each parasite. Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont.
引用总数
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NM El-Sayed, PJ Myler, G Blandin, M Berriman… - Science, 2005
