作者
Hubertus Himmerich, Pierre A Beitinger, Stephany Fulda, Renate Wehrle, Jakob Linseisen, Günther Wolfram, Stephanie Himmerich, Kurt Gedrich, Thomas C Wetter, Thomas Pollmächer
发表日期
2006/9/18
期刊
Archives of internal medicine
卷号
166
期号
16
页码范围
1739-1743
出版商
American Medical Association
简介
Background
Narcolepsy is a disabling sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis. Recent studies suggest that the immune system might play a pathogenic role pointing to a possible involvement of inflammatory cytokines.
Methods
We investigated a sample of 30 patients with narcolepsy in comparison with 120 sex- and age-matched and 101 sex-, body mass index (BMI)-, and age-matched randomly selected normal controls. In these groups, plasma concentrations of tumor necrosis factor α (TNF-α) and its soluble receptors p55 and p75 (soluble TNF receptor [sTNF-R] p55 and sTNF-R p75) were measured using commercial enzyme-linked immunosorbent assays.
Results
The narcoleptic patients showed a significantly higher BMI compared with controls of the same age. Soluble TNF-R p75 levels were consistently elevated in the …
学术搜索中的文章
H Himmerich, PA Beitinger, S Fulda, R Wehrle… - Archives of internal medicine, 2006