作者
Mary Cushman, Suzanne E Judd, Virginia J Howard, Brett Kissela, Orlando M Gutiérrez, Nancy S Jenny, Ali Ahmed, Evan L Thacker, Neil A Zakai
发表日期
2014/6
期刊
Stroke
卷号
45
期号
6
页码范围
1646-1650
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose
Improved identification of those at risk of stroke might improve prevention. We evaluated the association of the cardiac function biomarker N-terminal pro–B-type natriuretic peptide (NT-proBNP) with stroke risk in the 30 239 black and white participants of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort.
Methods
During 5.4 years of follow-up after enrollment in 2003 to 2007, NT-proBNP was measured in baseline blood samples of 546 subjects with incident ischemic stroke and 956 without stroke.
Results
NT-proBNP was higher with older age and in those with heart disease, kidney disease, atrial fibrillation, and lower low-density lipoprotein-cholesterol. Adjusting for age, race, sex, income, education, and traditional stroke risk factors, there was an increased risk of stroke across quartiles of NT-proBNP; participants with NT-proBNP in the top versus the bottom …
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M Cushman, SE Judd, VJ Howard, B Kissela… - Stroke, 2014