作者
Bakhtawar K Mahmoodi, Mary Cushman, Inger Anne Næss, Matthew A Allison, Willem Jan Bos, Sigrid K Brækkan, Suzanne C Cannegieter, Ron T Gansevoort, Philimon N Gona, Jens Hammerstrøm, John-Bjarne Hansen, Susan Heckbert, Anders G Holst, Susan G Lakoski, Pamela L Lutsey, JoAnn E Manson, Lisa W Martin, Kunihiro Matsushita, Karina Meijer, Kim Overvad, Eva Prescott, Marja Puurunen, Jacques E Rossouw, Yingying Sang, Marianne T Severinsen, Jur Ten Berg, Aaron R Folsom, Neil A Zakai
发表日期
2017/1/3
期刊
Circulation
卷号
135
期号
1
页码范围
7-16
出版商
Lippincott Williams & Wilkins
简介
Background
Much controversy surrounds the association of traditional cardiovascular disease risk factors with venous thromboembolism (VTE).
Methods
We performed an individual level random-effect meta-analysis including 9 prospective studies with measured baseline cardiovascular disease risk factors and validated VTE events. Definitions were harmonized across studies. Traditional cardiovascular disease risk factors were modeled categorically and continuously using restricted cubic splines. Estimates were obtained for overall VTE, provoked VTE (ie, VTE occurring in the presence of 1 or more established VTE risk factors), and unprovoked VTE, pulmonary embolism, and deep-vein thrombosis.
Results
The studies included 244 865 participants with 4910 VTE events occurring during a mean follow-up of 4.7 to 19.7 years per study. Age, sex, and body mass index-adjusted hazard ratios for overall VTE were 0 …
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BK Mahmoodi, M Cushman, I Anne Næss, MA Allison… - Circulation, 2017