作者
Paul D Stein, Pamela K Woodard, John G Weg, Thomas W Wakefield, Victor F Tapson, H Dirk Sostman, Thomas A Sos, Deborah A Quinn, Kenneth V Leeper Jr, Russell D Hull, Charles A Hales, Alexander Gottschalk, Lawrence R Goodman, Sarah E Fowler, John D Buckley
发表日期
2006/12/1
期刊
The American journal of medicine
卷号
119
期号
12
页码范围
1048-1055
出版商
Elsevier
简介
PURPOSE
To formulate comprehensive recommendations for the diagnostic approach to patients with suspected pulmonary embolism, based on randomized trials.
METHODS
Diagnostic management recommendations were formulated based on results of the Prospective Investigation of Pulmonary Embolism Diagnosis II (PIOPED II) and outcome studies.
RESULTS
The PIOPED II investigators recommend stratification of all patients with suspected pulmonary embolism according to an objective clinical probability assessment. D-dimer should be measured by the quantitative rapid enzyme-linked immunosorbent assay (ELISA), and the combination of a negative D-dimer with a low or moderate clinical probability can safely exclude pulmonary embolism in many patients. If pulmonary embolism is not excluded, contrast-enhanced computed tomographic pulmonary angiography (CT angiography) in combination with …
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