作者
Zhongheng Zhang, Baolong Lu, Xiaoyan Sheng, Ni Jin
发表日期
2011/9/1
来源
American Journal of Kidney Diseases
卷号
58
期号
3
页码范围
356-365
出版商
WB Saunders
简介
BACKGROUND
Cystatin C (CysC) has been proposed as a filtration marker for the early detection of acute kidney injury (AKI); however, a wide range of its predictive accuracy has been reported.
STUDY DESIGN
Meta-analysis of diagnostic test studies.
SETTING & POPULATION
Various clinical settings of AKI, including patients after cardiac surgery, pediatric patients, and critically ill patients.
SELECTION CRITERIA
Computerized search of PubMed, Current Contents, CINAHL, and EMBASE from inception until November 15, 2010, was performed to identify potentially relevant articles. Inclusion criteria were studies investigating the diagnostic accuracy of CysC level to predict AKI. There were no language restrictions in the search.
INDEX TESTS
Increasing or increased serum CysC level or urinary CysC excretion.
REFERENCE TESTS
The outcome was the development of AKI, primarily based on serum creatinine …
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