作者
Giampaolo Niccoli, Stefano Rigattieri, Maria Rosaria De Vita, Marco Valgimigli, Pierfrancesco Corvo, Franco Fabbiocchi, Enrico Romagnoli, Alberto Ranieri De Caterina, Giuseppe La Torre, Paolo Lo Schiavo, Fabio Tarantino, Roberto Ferrari, Fabrizio Tomai, Paolo Olivares, Nicola Cosentino, Domenico D'Amario, Antonio Maria Leone, Italo Porto, Francesco Burzotta, Carlo Trani, Filippo Crea
发表日期
2013/6
期刊
JACC: Cardiovascular Interventions
卷号
6
期号
6
页码范围
580-589
出版商
American College of Cardiology Foundation
简介
Objectives
This study sought to assess whether intracoronary adenosine or nitroprusside following thrombus aspiration (TA) is superior to TA alone for the prevention of microvascular obstruction (MVO) in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI).
Background
MVO, due to its multifactorial pathogenesis, still occurs after TA in a sizeable portion of patients.
Methods
We performed a placebo-controlled, randomized, open-label, blind-examination, multicenter trial. A total of 240 STEMI patients with Thrombolysis In Myocardial Infarction (TIMI) flow grade 0/1 were randomly allocated 1:1:1 to receive adenosine (n = 80), nitroprusside (n = 80), or saline (n = 80) given distal to the occluded site after TA. The primary endpoint was the incidence of ST-segment resolution (STR) >70% on surface electrocardiogram at 90 min after PCI. Secondary endpoints …
学术搜索中的文章
G Niccoli, S Rigattieri, MR De Vita, M Valgimigli… - JACC: Cardiovascular Interventions, 2013