作者
A Ramos Murguialday, Jeremy Hill, Michael Bensch, Suzanna Martens, Sebastian Halder, Femke Nijboer, Bernhard Schoelkopf, Niels Birbaumer, Alireza Gharabaghi
发表日期
2011/5/1
期刊
Clinical Neurophysiology
卷号
122
期号
5
页码范围
925-933
出版商
Elsevier
简介
OBJECTIVE
To clarify the physiological and behavioral boundaries between locked-in (LIS) and the completely locked-in state (CLIS) (no voluntary eye movements, no communication possible) through electrophysiological data and to secure brain–computer-interface (BCI) communication.
METHODS
Electromyography from facial muscles, external anal sphincter (EAS), electrooculography and electrocorticographic data during different psychophysiological tests were acquired to define electrophysiological differences in an amyotrophic lateral sclerosis (ALS) patient with an intracranially implanted grid of 112 electrodes for nine months while the patient passed from the LIS to the CLIS.
RESULTS
At the very end of the LIS there was no facial muscle activity, nor external anal sphincter but eye control. Eye movements were slow and lasted for short periods only. During CLIS event related brain potentials (ERP) to …
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