作者
Fritz-Patrick Jahns, John Paul Miroz, Mahmoud Messerer, Roy T Daniel, Fabio Silvio Taccone, Philippe Eckert, Mauro Oddo
发表日期
2019/12
期刊
Critical care
卷号
23
页码范围
1-9
出版商
BioMed Central
简介
Background
Elevated intracranial pressure (ICP) is frequent after traumatic brain injury (TBI) and may cause abnormal pupillary reactivity, which in turn is associated with a worse prognosis. Using automated infrared pupillometry, we examined the relationship between the Neurological Pupil index (NPi) and invasive ICP in patients with severe TBI.
Methods
This was an observational cohort of consecutive subjects with severe TBI (Glasgow Coma Scale [GCS] < 9 with abnormal lesions on head CT) who underwent parenchymal ICP monitoring and repeated NPi assessment with the NPi-200® pupillometer. We examined NPi trends over time (four consecutive measurements over intervals of 6 h) prior to sustained elevated ICP > 20 mmHg. We further analyzed the relationship of cumulative abnormal NPi burden (%NPi values < 3 during total ICP …
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FP Jahns, JP Miroz, M Messerer, RT Daniel… - Critical care, 2019