作者
María Isabel Navarro-Mendoza, Carlos Pérez-Arques, Shweta Panchal, Francisco E Nicolás, Stephen J Mondo, Promit Ganguly, Jasmyn Pangilinan, Igor V Grigoriev, Joseph Heitman, Kaustuv Sanyal, Victoriano Garre
发表日期
2019/11/18
期刊
Current Biology
卷号
29
期号
22
页码范围
3791-3802. e6
出版商
Elsevier
简介
Centromeres are rapidly evolving across eukaryotes, despite performing a conserved function to ensure high-fidelity chromosome segregation. CENP-A chromatin is a hallmark of a functional centromere in most organisms. Due to its critical role in kinetochore architecture, the loss of CENP-A is tolerated in only a few organisms, many of which possess holocentric chromosomes. Here, we characterize the consequence of the loss of CENP-A in the fungal kingdom. Mucor circinelloides, an opportunistic human pathogen, lacks CENP-A along with the evolutionarily conserved CENP-C but assembles a monocentric chromosome with a localized kinetochore complex throughout the cell cycle. Mis12 and Dsn1, two conserved kinetochore proteins, were found to co-localize to a short region, one in each of nine large scaffolds, composed of an ∼200-bp AT-rich sequence followed by a centromere-specific conserved motif …
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MI Navarro-Mendoza, C Pérez-Arques, S Panchal… - Current Biology, 2019