作者
Daniel Aliseda, Jorge Arredondo, Carlos Sánchez-Justicia, Alicia Alvarellos, Javier Rodríguez, Ignacio Matos, Fernando Rotellar, Jorge Baixauli, Carlos Pastor
发表日期
2024/2
来源
British Journal of Surgery
卷号
111
期号
2
页码范围
znae021
出版商
Oxford University Press
简介
Background
Neoadjuvant chemotherapy is increasingly used to treat locally advanced (T3–4 Nx–2 M0) colon cancer due to its potential advantages over the standard approach of upfront surgery. The primary objective of this systematic review and meta-analysis was to analyse data from comparative studies to assess the impact of neoadjuvant chemotherapy on oncological outcomes.
Methods
A systematic review was conducted by searching the MEDLINE and Scopus databases. The search encompassed RCTs, propensity score-matched studies, and controlled prospective studies published up to 1 April 2023. As a primary objective, overall survival and disease-free survival were compared. As a secondary objective, perioperative morbidity, mortality, and complete resection were compared using the DerSimonian and Laird models.
Results
A total of …
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D Aliseda, J Arredondo, C Sánchez-Justicia… - British Journal of Surgery, 2024