作者
Xia Wang, Wei Bao, Jun Liu, Ying-Ying OuYang, Di Wang, Shuang Rong, Xiao Xiao, Zhi-Lei Shan, Yan Zhang, Ping Yao, Lie-Gang Liu
发表日期
2013/1/1
期刊
Diabetes Care
卷号
36
期号
1
页码范围
166-175
出版商
American Diabetes Association
简介
OBJECTIVE
There has been growing evidence that inflammatory markers play a role in the development of type 2 diabetes. We aimed to systematically review prospective studies on the associations of elevated levels of interleukin-6 (IL-6) and C-reactive protein (CRP) with increased risk of type 2 diabetes by conducting a meta-analysis.
RESEARCH DESIGN AND METHODS
A systematic search of the PubMed, EMBASE, ISI Web of Knowledge, and Cochrane Library databases up until 10 February 2012 was conducted to retrieve prospective studies matched to search terms. We used generalized least-squares trend estimation to assess dose-response relationships. The summary risk estimates were pooled using either fixed-effects or random-effects models to incorporate between-study variation.
RESULTS
The meta-analysis, including 10 prospective studies …
学术搜索中的文章
X Wang, W Bao, J Liu, YY OuYang, D Wang, S Rong… - Diabetes care, 2013