作者
Olvert A Berkhemer, Ivo GH Jansen, Debbie Beumer, Puck SS Fransen, Lucie A Van Den Berg, Albert J Yoo, Hester F Lingsma, Marieke ES Sprengers, Sjoerd FM Jenniskens, Geert J Lycklama à Nijeholt, Marianne AA van Walderveen, René van den Berg, Joseph CJ Bot, Ludo FM Beenen, Anna MM Boers, Cornelis H Slump, Yvo BWEM Roos, Robert J van Oostenbrugge, Diederik WJ Dippel, Aad van der Lugt, Wim H van Zwam, Henk A Marquering, Charles BLM Majoie
发表日期
2016/3
期刊
Stroke
卷号
47
期号
3
页码范围
768-776
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose
Recent randomized trials have proven the benefit of intra-arterial treatment (IAT) with retrievable stents in acute ischemic stroke. Patients with poor or absent collaterals (preexistent anastomoses to maintain blood flow in case of a primary vessel occlusion) may gain less clinical benefit from IAT. In this post hoc analysis, we aimed to assess whether the effect of IAT was modified by collateral status on baseline computed tomographic angiography in the Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands (MR CLEAN).
Methods
MR CLEAN was a multicenter, randomized trial of IAT versus no IAT. Primary outcome was the modified Rankin Scale at 90 days. The primary effect parameter was the adjusted common odds ratio for a shift in direction of a better outcome on the modified Rankin Scale. Collaterals were graded from 0 (absent) to …
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OA Berkhemer, IGH Jansen, D Beumer, PSS Fransen… - Stroke, 2016