作者
Sophia Koukouraki, Ludwig G Strauss, Vassilios Georgoulias, Jochen Schuhmacher, Uwe Haberkorn, Nikolaos Karkavitsas, Antonia Dimitrakopoulou-Strauss
发表日期
2006/4
期刊
European journal of nuclear medicine and molecular imaging
卷号
33
页码范围
460-466
出版商
Springer-Verlag
简介
Purpose
The purpose of the study was to evaluate the pharmacokinetics of 68Ga-DOTATOC in order to ascertain which parameters have the greatest impact on the global DOTATOC standardised uptake value (SUV), defined as the mean SUV of the last frame of the dynamic study 55–60 min p.i.
Methods
Twenty-two patients with 74 metastatic lesions were examined with dynamic 68Ga-DOTATOC PET studies. Standardised uptake values (SUVs) were calculated for all frames following the injection of the tracer. We defined global SUV as the mean SUV of the last frame (frame duration 5 min) of the dynamic study 55–60 min p.i. A two-tissue compartment model with a blood compartment was used for the evaluation of the rate constants k 1 (receptor binding), k 2 (displacement from the receptor), k 3 (cellular …
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