作者
Sophia Koukouraki, Ludwig G Strauss, Vassilios Georgoulias, Michael Eisenhut, Uwe Haberkorn, Antonia Dimitrakopoulou-Strauss
发表日期
2006/10
期刊
European journal of nuclear medicine and molecular imaging
卷号
33
页码范围
1115-1122
出版商
Springer-Verlag
简介
Purpose
The purpose of this study was to evaluate and compare, by means of dynamic PET, the pharmacokinetics of 68Ga-DOTATOC, a tracer which reflects the expression of somatostatin receptors (SSTRs), and of [18F]FDG, a marker of tumour viability, in patients with metastatic neuroendocrine tumours (NETs) in whom 90Y-DOTATOC therapy was planned.
Materials and methods
Fifteen patients (63 lesions) with confirmed metastatic NETs were enrolled in this study. Dynamic [18F]FDG and 68Ga-DOTATOC PET scans were performed on two different days in the same week. The data analysis was based on qualitative and quantitative analysis using a two-tissue compartment model with a blood compartment and a non-compartment model based on the fractal dimension (FD). Multivariate analysis was used for evaluation of the kinetic data …
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S Koukouraki, LG Strauss, V Georgoulias, M Eisenhut… - European journal of nuclear medicine and molecular …, 2006