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DiscoverBMB Abstracts Cryptococcus during human infection, and that heat stress at human body temperature can significantly increase the TE mutation rate in C. neoformans. It is therefore possible that TE mutations in the genomes of cryptococci during infection contribute to microevolution and disease persistence in the host. Long-read whole-genome sequence analyses of the clinical isolates are in progress to map the locations of TE movements in relapse isolates to determine their contributions to phenotypic changes and fitness. This research was supported by National Institutes of Health grants R35GM118077 and R21AI133644 to SJR, and the NIH/NIAID K99 MOSAIC grant 1K99AI166094-01 to AG 103689, https://doi. org/10.1016/j. jbc. 2023.103689 Abstract 1420 Chemoproteomic Profiling Surveys the Degradable Proteome Katherine Donovan, Dana-Farber Cancer Institute Fleur Ferguson, Yuan Xiong …