作者
Ding-Fung Toh, Dhavalkumar Narendrabhai Patel, Eric Chun-Yong Chan, Alvin Teo, Soek-Ying Neo, Hwee-Ling Koh
发表日期
2011/1/24
期刊
Chinese medicine
卷号
6
期号
1
页码范围
1
出版商
BioMed Central
简介
Background
Panax notoginseng is a potential source of anticancer compounds. This study aims to investigate the effects of steaming on the chemical profile of P. notoginseng and the anti-proliferative effects of P. notoginseng on liver cancer cells.
Methods
Samples of powdered raw P. notoginseng roots were steamed for various durations. Extracts of the raw and steamed samples were subjected to ultra-high pressure liquid chromatography/mass spectrometry (UHPLC-MS) analysis for chemical profiling. The anti-proliferative effects on three human liver cancer cells, namely SNU449, SNU182 and HepG2, were evaluated using colorimetric WST-1 assay.
Results
Steaming changed chromatographic and pharmacological profiles of P. notoginseng, causing differences in activities such as inhibition of cancer growth …
学术搜索中的文章
DF Toh, DN Patel, ECY Chan, A Teo, SY Neo, HL Koh - Chinese Medicine, 2011