作者
Lee Cheng Phua, Xiu Ping Chue, Poh Koon Koh, Peh Yean Cheah, Han Kiat Ho, Eric Chun Yong Chan
发表日期
2014/4/1
期刊
Cancer biology & therapy
卷号
15
期号
4
页码范围
389-397
出版商
Taylor & Francis
简介
Colorectal cancer (CRC) is a major cause of mortality in many developed countries. Effective screening strategies were called for to facilitate timely detection and to promote a better clinical outcome. In this study, the role of fecal metabonomics in the non-invasive detection of CRC was investigated. Gas chromatography/time-of-flight mass spectrometry (GC/TOFMS) was utilized for the metabolic profiling of feces obtained from 11 CRC patients and 10 healthy subjects. Concurrently, matched tumor and normal mucosae surgically excised from CRC patients were profiled. CRC patients were differentiated clearly from healthy subjects based on their fecal metabonomic profiles (orthogonal partial least squares discriminant analysis [OPLS-DA], 1 predictive and 3 Y-orthogonal components, R2X = 0.373, R2Y = 0.995, Q2 [cumulative] = 0.215). The robustness of the OPLS-DA model was demonstrated by an area of 1 under …
学术搜索中的文章
LC Phua, XP Chue, PK Koh, PY Cheah, HK Ho… - Cancer biology & therapy, 2014