作者
Steven Z Pavletic, Paul Martin, Stephanie J Lee, Sandra Mitchell, David Jacobsohn, Edward W Cowen, Maria L Turner, Gorgun Akpek, Andrew Gilman, George McDonald, Mark Schubert, Ann Berger, Peter Bross, Jason W Chien, Daniel Couriel, JP Dunn, Jane Fall-Dickson, Ann Farrell, Mary ED Flowers, Hildegard Greinix, Steven Hirschfeld, Lynn Gerber, Stella Kim, Robert Knobler, Peter A Lachenbruch, Frederick W Miller, Barbara Mittleman, Esperanza Papadopoulos, Susan K Parsons, Donna Przepiorka, Michael Robinson, Michael Ward, Bryce Reeve, Lisa G Rider, Howard Shulman, Kirk R Schultz, Daniel Weisdorf, Georgia B Vogelsang
发表日期
2006/3/1
来源
Biology of Blood and Marrow Transplantation
卷号
12
期号
3
页码范围
252-266
出版商
Elsevier
简介
The lack of standardized criteria for quantitative measurement of therapeutic response in clinical trials poses a major obstacle for the development of new agents in chronic graft-versus-host disease (GVHD). This consensus document was developed to address several objectives for response criteria to be used in chronic GVHD-related clinical trials. The proposed measures should be practical for use both by transplantation and nontransplantation medical providers, adaptable for use in adults and in children, and focused on the most important chronic GVHD manifestations. The measures should also give preference to quantitative, rather than semiquantitative, measures; capture information regarding signs, symptoms, and function separately from each other; and use validated scales whenever possible to demonstrate improved patient outcomes and meet requirements for regulatory approval of novel agents …
引用总数
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SZ Pavletic, P Martin, SJ Lee, S Mitchell, D Jacobsohn… - Biology of Blood and Marrow Transplantation, 2006