作者
William J Sandborn, Edward V Loftus Jr, Jean Frederic Colombel, Kenneth A Fleming, Frank Seibold, Henry A Homburger, Boualem Sendid, Roger W Chapman, William J Tremaine, Debra K Kaul, Jeannie Wallace, William S Harmsen, Alan R Zinsmeister, Stephan R Targan
发表日期
2001/8/1
期刊
Inflammatory bowel diseases
卷号
7
期号
3
页码范围
192-201
出版商
Oxford University Press
简介
Background
The sensitivity of assays for antineutrophil cytoplasmic antibody (ANCA), anti-Saccharomyces cerevisiae antibody (ASCA), and antipancreatic antibody (PAB) in different laboratories is unknown. Likewise, the sensitivity and diagnostic usefulness of these assays in patients with inflammatory bowel disease (IBD) in the community is unknown.
Methods
An incidence cohort of 290 patients with IBD were offered participation in the study. Blood was obtained from 162 patients (56%) (83 with ulcerative colitis, 79 with Crohn's disease) who agreed to participate. ANCA was determined in five laboratories, ASCA in two laboratories, and PAB in one laboratory.
Results
In ulcerative colitis, the sensitivity of ANCA determined in five laboratories varied widely, ranging from 0–63%. In Crohn's disease, the sensitivity of ASCA determined in two laboratories did …
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WJ Sandborn, EV Loftus Jr, JF Colombel, KA Fleming… - Inflammatory bowel diseases, 2001