作者
Wengang Wang, Tailong Chen, Yibin Liu, Songsong Wang, Ningning Yang, Ming Luo
发表日期
2022/9
来源
European Spine Journal
卷号
31
期号
9
页码范围
2311-2325
出版商
Springer Berlin Heidelberg
简介
Purpose
Genetic diagnosis is a promising approach because several single-nucleotide polymorphisms (SNPs) associated with adolescent idiopathic scoliosis (AIS) progression have been reported. We review the predictive value of SNPs in curve progression of adolescent idiopathic scoliosis.
Methods
We reviewed DNA-based prognostic testing to predict curve progression. Then, the multiple polymorphisms in loci related to AIS progression were also reviewed, and we elucidated the predictive value of SNPs from four functional perspectives, including endocrine metabolism, neuromuscular system, cartilage and extracellular matrix, enzymes, and cytokines.
Results
The ScoliScores were less successful predictors than expected, and the weak power of predictive SNPs might account for its failure. Susceptibility loci in ESR1, ESR2, GPER, and IGF1, which related to endocrine metabolism, have been reported to predict …
学术搜索中的文章
W Wang, T Chen, Y Liu, S Wang, N Yang, M Luo - European Spine Journal, 2022