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METHODS

We reviewed 10361 men with prostate cancer treated at two centers from 1995 to 2007. Pretreatment medical comorbidity was measured by validated comorbidity indices. 6692 men with no recorded medical comorbidities underwent radical prostatectomy (RP), external-beam radiotherapy (EBR), or brachytherapy (BT). Patients were stratified by age< 65 or≥ 65 years. Analyses with Cox proportional hazards identified variables associated with survival (PCM= prostate cancer mortality, OM= overall mortality) which were incorporated into a multivariate Cox model with RP as the reference group with hazard ratio (HR) of 1.0.

RESULTS

Treatment utilization differed in men under age 65 (RP: 3361, EBR: 393, BT: 398) compared to age 65 and over (RP: 1098, EBR: 868, BT: 574). Over a median follow-up of 66.4 months, 538 of 6692 men died including 101 of PCM. In multivariable analysis, no significant …