作者
Martin G Sanda, Rodney L Dunn, Jeff Michalski, Howard M Sandler, Laurel Northouse, Larry Hembroff, Xihong Lin, Thomas K Greenfield, Mark S Litwin, Christopher S Saigal, Arul Mahadevan, Eric Klein, Adam Kibel, Louis L Pisters, Deborah Kuban, Irving Kaplan, David Wood, Jay Ciezki, Nikhil Shah, John T Wei
发表日期
2008/3/20
期刊
New England Journal of Medicine
卷号
358
期号
12
页码范围
1250-1261
出版商
Massachusetts Medical Society
简介
Background
We sought to identify determinants of health-related quality of life after primary treatment of prostate cancer and to measure the effects of such determinants on satisfaction with the outcome of treatment in patients and their spouses or partners.
Methods
We prospectively measured outcomes reported by 1201 patients and 625 spouses or partners at multiple centers before and after radical prostatectomy, brachytherapy, or external-beam radiotherapy. We evaluated factors that were associated with changes in quality of life within study groups and determined the effects on satisfaction with the treatment outcome.
Results
Adjuvant hormone therapy was associated with worse outcomes across multiple quality-of-life domains among patients receiving brachytherapy or radiotherapy. Patients in the brachytherapy group reported having long-lasting urinary irritation, bowel and sexual symptoms, and …
引用总数
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MG Sanda, RL Dunn, J Michalski, HM Sandler… - New England Journal of Medicine, 2008