作者
Janet Dancey, Edward A Sausville
发表日期
2003/4/1
来源
Nature reviews Drug discovery
卷号
2
期号
4
页码范围
296-313
出版商
Nature Publishing Group UK
简介
Identification of the key roles of protein kinases in cancer has led to extensive efforts to develop kinase inhibitors for the treatment of a wide range of cancers, and more than 30 such agents are now in clinical trials. Here, we consider the crucial issues in the development of kinase inhibitors for cancer, and discuss strategies to address the challenges raised by these issues in the light of preclinical and clinical experiences so far.
引用总数
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