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The revised classification criteria for the antiphospholipid syndrome state that antiphospholipid (aPL) antibodies (lupus anticoagulant [LAC] and/or anticardiolipin [aCL] and/or anti‐β₂‐glycoprotein I [aβ₂GPI] antibodies) should be detected on two or more occasions at least 12 weeks apart. Consequently, classification of patient risk and adequacy of treatment may be deferred by 3 months.

In order to early classify patient risk, we evaluated whether aPL positivity confirmation is related to aPL antibody profiles.

Consecutive patients referred to our center who were initially positive in one or more tests exploring the presence of aPL were tested after 3 months. During a 4‐year period, 225 patients were initially positive in one or more tests, and 161 were available for confirmation after 3 months. Patients were classified as triple‐positive (n = 54: LAC⁺, aCL⁺, aβ₂GPI⁺, same …