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The high resistance of bacteria against conventional pharmaceutical solutions, the antibiotics, has raised serious global public-health concerns. This has stimulated interest in the research of bio-based therapeutics with limited resistance, namely, antimicrobial peptides (AMPs) or essential oils (EOs). This study envisaged the evaluation of the antimicrobial efficacy of selected biomolecules, namely LL37, pexiganan, tea tree oil (TTO), cinnamon leaf oil (CLO) and niaouli oil (NO), against four bacteria commonly associated to nosocomial infections: Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa. The antibiotic vancomycin and silver nanoparticles (AgNPs) were used as control for comparison purposes. The biomolecules were initially screened for their antibacterial activity using the agar-diffusion test, followed by the determination of minimal inhibitory …