作者
Mohammed Elmowafy, Khaled Shalaby, Ayman Salama, Ghareb M Soliman, Nabil K Alruwaili, Ehab M Mostafa, Elshaer F Mohammed, Abd El Ghany A Moustafa, Ameeduzzafar Zafar
发表日期
2019/5
期刊
Journal of Pharmacy and Pharmacology
卷号
71
期号
5
页码范围
774-787
出版商
Oxford University Press
简介
Objectives
This study aims to develop thermosensitive gel containing soy isoflavone (antioxidant and anti-inflammatory natural agent) alginate microspheres for enhancement of wound-healing performance.
Methods
Soy isoflavone microspheres were prepared by ionic cross-linking method and optimized using the Box–Behnken optimization design. Formulations were characterized in terms of particle size, encapsulation efficiency and equilibrium swelling degree. The optimized formula was incorporated in Pluronic F127 gel base and examined for in vivo wound-healing efficacy.
Key findings
Results showed mean particle size between 18 and 25 μm, encapsulation efficiency of over 75% and equilibrium swelling degree over 1.9. Thermal analysis indicated interaction between alginate and CaCl2 and embedding of soy isoflavone in microspheres. In vivo …
学术搜索中的文章
M Elmowafy, K Shalaby, A Salama, GM Soliman… - Journal of Pharmacy and Pharmacology, 2019